Combination of PPI with a Prokinetic drug in Gastroesophageal reflux disease  

Oleh:

Ndraha, Suzanna

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Acta Medica Indonesiana vol. 43 no. 04 (Oct. 2011), page 233-236.
Topik: GERD; FSSG; omeprazole; domperidone
Fulltext: Combination of PPI.pdf (759.43KB)

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Perpustakaan FK Nomor Panggil: A02.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Aim: to evaluate the efficacy of combination of PPI with prokinetic drug compared to PPI mono therapy in GERD patients with high frequency scale for the symptoms of GERD (FSSG) score. Methods: sixty dyspeptic patients having heartburn and/or regurgitation were recruited during the period of July 2010 – April 2011 in this double blind clinical trial. By randomization, they were divided into two groups; group A was given omeprazole 2x20 mg and domperidone 3x10 mg for 2 weeks, while another group was only given omeprazole 2x20 mg. The FSSG score was performed before treatment and after 2 weeks of treatment. Results: there were 20 (33%) males and 40 (67%) females. The mean total score of FSSG was 25.3+8.2 at pretest, and 19.3+9.7 at posttest, with improvement of 6.1+4.9. The FSSG score in group A after treatment (19.3±11.3) was significantly lower than before treatment (26.7±8.9, p<0.001) as well as in group B (from 23.9±7.3 to 19,3±7.9, p<0.001). The mean improvement score in group A was 7.5±5.9, while in the group B was of 4.6±3.3, and this difference was statistically significant (p=0.02) Conclusion: combination of omeprazole with domperidone in GERD patients with high FSSG score is more superior compared to omeprazole monotherapy.

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