Metformin decreases serum 8-hydroxy-2'-deoxyguanosine levels in polycystic ovary syndrome  

Oleh:

Sova, Henri ; Puistola, Ulla ; Morin-Papunen, Laure C. ; Karihtala, Peeter

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 99 no. 02 (Feb. 2013), page 593-598.
Topik: 8-OHdG; metformin; oxidative stress; polycystic ovary syndrome; reactive oxygen species

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2013.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To learn whether metformin treatment affects oxidative stress as measured by serum concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG). Design Double-blind, randomized, placebo-controlled trial. Setting University outpatient clinic. Patient(s) The study cohort consisted of 50 obese women (body mass index [BMI] =27 kg/m2) and 60 nonobese patients (BMI <27 kg/m2), mean age was 27.7 ± 4.0 SD years. Intervention(s) Randomization to receive metformin or placebo for 3 months. Main Outcome Measure(s) Serum levels of 8-OHdG before and after medical treatment. Result(s) The levels of 8-OHdG were equal at baseline in the placebo and metformin groups. Obese women had higher baseline serum concentrations of 8-OHdG. Levels of 8-OHdG were statistically significantly reduced with metformin treatment, especially in obese patients with polycystic ovary syndrome. This study was a secondary subanalysis of a previously conducted prospective multicenter, randomized, placebo-controlled study on the effects of metformin on miscarriage, pregnancy, and miscarriage rates. Conclusion(s) Metformin treatment, compared with placebo, statistically significantly decreased 8-OHdG levels in women with polycystic ovary syndrome.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali