A common variant in the peroxisome proliferator–activated receptor-? coactivator-1a gene is associated with nonalcoholic fatty liver disease in obese children  

Oleh:

Lin, Yu-Cheng ; Chang, Pi-Feng ; Chang, Mei-Hwei ; Ni, Yen-Hsuan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 97 no. 02 (Feb. 2013), page 326-331.
Topik: LIVER DISEASES; Obese Taiwanese children

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2013.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: The single nucleotide polymorphism in the peroxisome proliferator–activated receptor-? coactivator (PGC)-1a gene (PPARGC1A) was identified to be associated with nonalcoholic fatty liver disease (NAFLD) in adults. The PPARGC1A gene encodes PGC-1a, which regulates cellular energy metabolism. Objective: We aimed to test the hypothesis that the PPARGC1A rs8192678 risk A allele would influence the risk of NAFLD in obese children. Design: We genotyped PPARGC1A rs8192678 and PNPLA3 rs738409 in 781 obese children aged 7–18 y. NAFLD was determined by ultrasonography. We evaluated the independent influence of the PPARGC1A rs8192678 risk A allele on pediatric NAFLD after control for the effect of the PNPLA3 rs738409 polymorphism. Results: A total of 23.3% of the recruited obese children had NAFLD. PNPLA3 rs738409 increased the OR of NAFLD by 1.622 (95% CI: 1.071, 2.457; P = 0.023) in subjects with GC alleles and 2.659 (95% CI: 1.509, 4.686; P < 0.001) for GG alleles, as compared with CC alleles. After control for the effects of age- and sex-adjusted BMI, sex, and PNPLA3 rs738409 polymorphism, the PPARGC1A rs8192678 risk A allele was an independent risk factor for developing NAFLD, with an OR of 1.740 (95% CI: 1.149, 2.637; P = 0.009). Subjects with the PPARGC1A rs8192678 risk A allele had an increase in the mean serum alanine aminotransferase concentration of 5.2 IU/L, as compared with subjects without this allele (P = 0.011). Conclusion: The PPARGC1A rs8192678 risk A allele is associated with an increased risk of NAFLD, independent of the effect of the PNPLA3 rs738409 polymorphism in our population of obese Taiwanese children.

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