Uji Banding Efektivitas Kalsipotriol Topikal, Suction Blister Grafting dan Kombinasi Keduanya pada Terapi Repigmentasi Lesi Vitiligo Stabil  

Oleh:

Nurhayati, Diana

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Media Medika Indonesiana vol. 46 no. 02 (May 2012), page 114-120.
Topik: Stable vitiligo; suction-blister-grafting; calcipotriol; repigmentation.

Ketersediaan

Perpustakaan FK Nomor Panggil: M30.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Comparison study the efficacy of topical calcipotriol, suction blister grafting and combination of both therapies for repigmentationc of stable vitiligo Background: Stable vitiligo is defined as non-progressive vitiligo for more than 6-month. A large variety of therapeutic agents are being tried, but an optimal treatment is not yet available. Topical calcipotriol is one of those agent that hypothetically can stimulate repigmentation of vitiliginous lesions. Suction-blister-grafting (SBG), is one of the surgical therapies for replenishment of melanocytes in stable vitiligo. The aim of this study was to compare the efficacy of topical calcipotriol, SBG and the combination of both therapies in the treatment of stable vitiligo. Methods: Twenty-one stable vitiligo (focal, segmental, and generalized) patients were selected for study. Patients were divided into three groups. First-groups were advised to apply topical calcipotriol (50ug/mg) twice-daily over the vitiliginous patches. Secondgroups were given with SBG, and third-groups were given with combination of both treatments. The main outcome measurement was the evaluation of the percentage of repigmentation in treated target lesions in 12-weeks. Results: After12-weeks periods, the combination therapies were found more effective than single therapy. The combination therapies-treated areas showed marked intense repigmentation improvement 19.1% compared to 15.1% on the SBG-only side (p<0.05). Calcipotriol was found to induce initiating repigmentation, but was not statistically significant. Conclusion: Combination therapy of SBG and topical calcipotriol is more effective than single therapy for stable vitiligo.

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