Korelasi Kadar TNF-a dan Skor Psoriasis Area and Severity Index (PASI) pada Pasien Psoriasis  

Oleh:

Budiastuti, Asih

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Media Medika Indonesiana vol. 45 no. 02 (May 2011), page 133-137.
Topik: Psoriasis; TNF-a; PASI score

Ketersediaan

Perpustakaan FK Nomor Panggil: M30.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Correlation of serum TNF-a levels and psoriasis area and severity index (PASI) score in psoriatic patients Backround: Psoriasis is a chronic inflammatory disease characterized by erythematous scaly patches. Psoriasis affects ±2.5% of world population, and 20-30% patients have moderate to severe psoriasis. Psoriatic patients have increased proinflammatory Th1 cytokines expression, including TNF-a, with relative deficiency of Th2 cytokines. Psoriasis area and severity index (PASI) is a subjective method which commonly used to measure disease severity. This study was aimed to determine the correlation between serum TNF-a level and PASI score, in order to obtain objective method for measuring disease severity. Method: This was an observational study performed psoriatic patients. Subjects underwent PASI score examination and serum TNF-a assay using ELISA. Result: Subjects were 16 patients (6 females and 10 males), with mean age of 51 years. Serum TNF-a levels ranged from 15,0-202,4 pg/mL. PASI score ranged from 0,3-55,8. The test showed no significant correlation between PASI score and serum TNF-a level. (?=-0,265; p=0,322) Conclusion: Serum TNF-a can not be used as clinical parameter of psoriasis severity.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali