Ekstrak Bawang Putih (Allium sativum) dan Ekspresi Insulin serta Derajat Insulitis Pankreas Tikus Sprague-Dawley yang Diinduksi Streptozotocin  

Oleh:

Dewi, Meira ; Wijaya, Indra ; Wijayahadi, Noor

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Media Medika Indonesiana vol. 45 no. 02 (May 2011), page 105-112.
Topik: Allium sativum; streptozotocin; insulin expression; level of insulitis

Ketersediaan

Perpustakaan FK Nomor Panggil: M30.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Allium sativum, insulin expression and insulitis degree of pancreas Sprague-Dawley rat induced by streptozotocin Background: The organic-sulphur content in Allium sativum has been scientifically proven to be a potent insulin-mimetic, antioxidant, and anti-inflammation agent by inhibiting the activity of NF-?ß. This research is aimed at finding out the effect of Allium sativum extract towards insulitis level and insulin expression in pancreas of Sprague-Dawley male rats. Method: This research used a randomized post test only controlled group design. There were 28 rats, two were randomly selected for the initial blood glucose test prior to treatment, two were selected on the tenth day after streptozotocin induction to ensure that all rats were in hyperglycaemia condition, and the remains as many as 24 rats were grouped into four groups: three treatment groups were administered with Allium sativum in levelled doses of 0.1, 0.25, 0.5 grams/kgBW/day for 14 days, and one group were act as control negative. Kruskall Wallis test continued with Mann Whitney test were used, with significance level of p<0.05. Results: The insulitis level and insulin expression of rats’ pancreas in the three treatment groups showed significant difference compared with the group without treatment showing dose-dependent result. However, it was not able to completely restore the damage pancreas. Conclusion: Allium sativum extract may play important role in restoring damage pancreas.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali