Deteksi P.Vivax Single Nucleotide Polymorphism (SNP) Y976f dari Sampel Monitoring Pengobatan Dihidroartemisinin-Piperakuin di Kalimantan dan Sulawesi  

Oleh:

Salwati, Ervi ; Herman, Reni ; Handayani, Sarwo ; Tjitra, Emiliana

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Media Penelitian dan Pengembangan Kesehatan vol. 22 no. 03 (Sep. 2012), page 112-119.
Topik: P.vivax; pvmdr1; Single Nucleotide Polymorphism
Fulltext: DETEKSI P.VIVAX SINGLE.pdf (268.22KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: M32.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

This study was a part of the activity of monitoring Dihydroartemisinin-Piperaquine (DHP) treatment in subjects infected with P.falciparum and P.vivax in Kalimantan and Sulawesi. SNP Y976F had been proved as the mutation in pvmdr1 gene which was related to P. vivax resistance chloroquine in Papua. Data of spreading pvmdr1 SNP Y976F outside Papua is needed for using Dihidroartemisinin-Piperakuin policy in the treatment of vivax malaria in Indonesia. Detection of SNP Y976F was done against 95 day0-samples of subjects confirmed infected with P.vivax or mixed infection of P.vivax and P.falciparum by PCR. The results showed that 88 (93%) of a total 95 samples were positive detected 976F mutant which were distributed in all sentinel sites of West Kalimantan (2of 3), Central Kalimantan (6 of 8), North Sulawesi (63 of 65), and Central Sulawesi (17 of 19). In conclusion, pvmdr1 SNP Y976F has been spreaded in all sentinel sites.

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