Laju Filtrasi Glomerulus pada Lansia Berdasarkan Tes Klirens Kreatin dengan Formula Cockroft-Gault, Cockroft-Gault Standardisasi, dan Modification of Diet in Renal Disease  

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Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Penelitian Lembaga Penelitian Universitas Sanata Dharma vol. 13 no. 02 (May 2010), page 217-225.
Topik: Creatinine Clearance; Elderly
Fulltext: J89 V13 N2 2010 P217.pdf (77.27KB)

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Perpustakaan PKPM Nomor Panggil: J89.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Background: Glomerular Filtration Rate (GFR) is a renal function index, which is measured indirectly by creatinine clearance. National Kidney Foundation Kidney Desease Outcome Quality Initiative (NKF KDOQI) has recommended estimation of GFR in adult based on Cockroft-Gault equation and Modification of Diet in Renal Desease (MDRD) formula. The decline in creatinine clearance in associated with advancing age. Succesful in therapeutic for elderly is determined by appropriate drug dose, which is associated with estimation of GFR. Objective: To evaluate estimation of GFR in elderly based on Cockroft-Gault equation, Standaritation of Cockroft-Gault equation and Modification of Diet in Renal Disease (MDRD) formula. Materials and Methods: The study was cross sectional design. The subjects were 57, with inclusion criteria, i.e. aged > 60 years, have creatinine and blood urea nitrogen in reference range, did not have stroke, renal disease and cardiovaskular diseases. All subjects were measured renal function test, i.e. level of creatinine, BUN and uric acid in serum and estimation of GFR based on formulas. Data analysis were done by unpaired t-test and one way Anova. Results: There were no significanty difference on estimation of GFR between men (47±8,8 ml/min) and women (43,3 ±14,7 ml/min) based on Cockroft-Gault equation; there were significantly difference on estimation of GFR between men (56,19 ± 10,7 ml/min) and women (69,8 ± 17,03 ml/min) based on Standaritation of Cockroft-Gault equation; there were no significanty difference on estimation of GFR between men (81,54 ± 16,6 ml/min) and women (78,79 ± 13,7 ml/min) based on Modification of Diet on Renal Disease (MDRD). There were significanty difference on mean estimation of clearance creatinine from the formulas. Mean estimation of clearance creatinine from MDRD formula was almost same with the other study. Conclutions: There were significanty difference on mean estimation of clearance creatinine in elderly based on Cockroft-Gault equation, Standaritation of Cockroft-Gault equation and Modification of Diet in Renal Disease (MDRD) formula.

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