Thrombospondin-1 and Transforming Growth Factor-ß1 Levels in Prolactinoma and Their Clinical Significance  

Oleh:

Jiang, M. ; Mou, C.Z. ; Han, T. ; Wang, M. ; Yang, W.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 40 no. 04 (Jul. 2012), page 1284-1294.
Topik: Nvasiveness; Microvessel Density; Prolactinoma; Thrombospondin-1; Transforming Growth Factor-?1

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE: To investigate the roles of angiogenesis, thrombospondin-1 (TSP-1) and transforming growth factor-ß1 (TGF-ß1) in invasive and noninvasive prolactinoma. METHODS: TSP-1 and TGF-ß1 protein were examined using immunohistochemistry and Western blotting in 81 prolactinomas. Angiogenesis was assessed by measuring microvessel density via CD34 immunostaining. RESULTS: Microvessel density was significantly higher in invasive prolactinomas than in noninvasive prolactinomas. Immunohistochemistry demonstrated that significantly fewer invasive prolactinomas were positive for TSP-1 compared with noninvasive prolactinomas (17.9% versus 50.0%, respectively), and significantly higher numbers of invasive prolactinomas were positive for TGF-ß1 compared with noninvasive prolactinomas (82.1% versus 42.9%, respectively). Microvessel density was significantly lower in TSP-1-positive prolactinomas than in TSP-1-negative prolactinomas, and significantly higher in TGF-ß1-positive prolactinomas than in TGF-ß1-negative prolactinomas. CONCLUSIONS: These results suggest a close relationship between angiogenesis and tumour invasiveness in prolactinoma. TSP-1 and TGF-ß1 may play important roles in the progression of prolactinoma, by affecting angiogenesis.

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