Serum levels of antimüllerian hormone in early maturing girls before, during, and after suppression with GnRH agonist  

Oleh:

Hagen, Casper P. ; Sorensen, Kaspar ; Anderson, Richard A. ; Juul, Anders

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 98 no. 05 (Nov. 2012), page 1326-1330.
Topik: REPRODUCTIVE ENDOCRINOLOGY; AMH; MIS; GnRH agonist; precocious puberty

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate whether serum antimüllerian hormone (AMH) levels are affected in early maturing girls, and whether pituitary suppression by long-acting GnRH agonist (GnRH-a) affects AMH. Design Secondary analyses of a prospective clinical study. Setting Tertiary pediatric center. Patient(s) Fifteen girls followed during GnRH-a treatment. Evaluations before, 3 and 12 months after initiation, as well as 6 months after discontinuation of treatment. To evaluate whether AMH levels were affected in early maturing girls, baseline levels were compared with levels in healthy girls (matched for age, n = 129; matched for pubertal Tanner stage, n = 119). Intervention(s) Patients were treated with SC injections of leuprolide acetate (LA; Procren 3.75 mg every 28th day). Main Outcome Measure(s) Basal serum levels of AMH, E2, inhibin B, FSH, and LH, as well as GnRH-stimulated levels of FSH and LH. Result(s) At baseline, the median (range) of AMH levels in the patients was 20.3 pmol/L (2.0–30.0 pmol/L). After 3 months of GnRH-a treatment, AMH declined to 10.4 pmol/L (range, <2.0–27.0 pmol/L). The AMH suppression was maintained after 12 months of treatment (14.4 pmol/L [range, <2.0–29.6 pmol/L]). Six months after discontinuation of GnRH-a treatment, AMH levels were similar to pretreatment levels (18.8 pmol/L (range, 5.8–46.9 pmol/L)). Before treatment, AMH levels in early maturing girls did not differ significantly from AMH levels in healthy age-matched girls (median, 20 vs. 23 pmol/L) or Tanner-matched girls (median, 20 vs. 19 pmol/L). Conclusion(s) The partial suppression of AMH by GnRH-a treatment is consistent with previous studies suggesting partial gonadotropin-dependence of AMH.

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