Platelet aggregation abnormalities in patients with fetal losses: the GP6 gene polymorphism  

Oleh:

Sokol, Juraj ; Biringer, Kamil ; Skerenova, Maria ; Hasko, Miroslav

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 98 no. 05 (Nov. 2012), page 1170-1174.
Topik: EARLY PREGNANCY; Platelets; hyperaggregability; fetal loss; glycoprotein VI; single-nucleotide polymorphism

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To evaluate the GP6 gene polymorphism in patients with sticky platelet syndrome (SPS) and fetal loss. Design Genetic association study. Setting Perinatal center. Patient(s) Twenty-seven patients with SPS, manifested as fetal loss, and 42 control subjects without SPS and no history of fetal loss and thrombosis. Intervention(s) SPS was diagnosed by platelet aggregometry (PACKS-4 aggregometer; Helena Laboratories). Seven single-nucleotide polymorphisms (SNPs) of the GP6 gene were evaluated. Main Outcome Measure(s) Occurrence of SNPs of the GP6 gene in SPS patients versus control subjects. Result(s) We found a higher occurrence of three SNPs of the GP6 gene in SPS patients versus control subjects (rs1671153: 0.204 vs. 0.048, odds ratio [OR] 5.116, 95% confidence interval [CI] 1.536–17.03; rs1654419: 0.204 vs. 0.071, OR 3.326, 95% CI 1.149–9.619; rs1613662: 0.204 vs. 0.071, OR 3.326, 95% CI 1.149–9.619). The haplotype analysis showed a significantly higher occurrence of two haplotypes (CTGAG in haplotype 5: 0.185 vs. 0.059, OR 3.568, 95% CI 1.142–11.14; and CGATAG in haplotype 6: 0.204 vs. 0.048, OR 4.961, 95% CI 1.488–16.53). Conclusion(s) Our results, especially the higher occurrence of haplotypes CTGAG and CGATAG in SPS patients, support the idea that GP6 gene polymorphism may be associated with platelet hyperaggregability, a possible cause of fetal loss.

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