The CC-allele of the PvuII polymorphic variant in intron 1 of the a-estrogen receptor gene is significantly more prevalent among infertile women at risk of premature ovarian aging  

Oleh:

M'Rabet, Nadira ; Moffa, Rebecca ; Helbling, Sabine ; Kaech, Andrea

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 98 no. 04 (Oct. 2012), page 965-972.
Topik: GENETICS; FSH receptor; estrogen receptor; polymorphism; premature ovarian failure; infertility

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To study the distribution of a set of polymorphic alleles of genes encoding key regulators of the menstrual cycle in cohorts of women with different levels of fertility. Design Prospective cohort study. Setting University hospital. Patient(s) Two hundred fertile women, who reported to have conceived within 3 months, 348 women with ongoing menstrual cycles suffering of infertility, and 48 infertile women diagnosed with infertility and premature ovarian failure (POF). Intervention(s) Eleven polymorphisms of genes with known associations with surrogate parameters of female ovarian function were analyzed. Main Outcome Measure(s) The prevalence of polymorphic alleles in the three distinct cohorts after adjustment for age. Result(s) The distributions of the allelic variants were compared with the fertility status of the recruited women. Using age-adjusted logistic regression analysis and the Bonferroni correction for multiple corrections, the CC-allele of the PvuII polymorphic variant in intron 1 of the ESR1 gene was twice as prevalent among women suffering from infertility. None of the other polymorphisms were distributed differently among the three cohorts. Conclusion(s) The ESR1-PvuII polymorphism emerges as a potential candidate for the early prediction of infertility due to premature ovarian aging.

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