The effect of timing of embryonic progression on chromosomal abnormality  

Oleh:

Kroener, Lindsay ; Ambartsumyan, Gayane ; Briton-Jones, Christine ; Dumesic, Daniel A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 98 no. 04 (Oct. 2012), page 876-880.
Topik: REPRODUCTION; Blastocyst; morula; embryonic progression; morphology; aneuploidy; preimplantation genetic screening; comparative genomic hybridization; in vitro fertilization

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate the relationship between aneuploidy and timing of blastocyst formation. Design Historical cohort study. Setting Private IVF clinic. Patient(s) Ninety-four couples undergoing IVF treatment in combination with chromosomal screening of embryos. The mean maternal age was 39.2 years and average number of embryos per patient 5.3. Intervention(s) A total of 530 embryos were biopsied on day 3 and underwent chromosome screening with microarray-based comparative genomic hybridization. Main Outcome Measure(s) Effect of day of embryo blastulation and morphologic grade on aneuploidy rate. Result(s) Day 5 morulas that progressed to blastocysts on day 6 were significantly less likely to be aneuploid (79.8%) than day 5 morulas that did not progress to blastocysts (92.9%). However, there was no significant difference in aneuploidy rates when embryos that became blastocysts on day 5 were directly compared with embryos that became blastocysts on day 6. Conclusion(s) Delayed blastulation is not associated with increased aneuploidy rates, but absence of blastulation is associated with increased aneuploidy. Therefore, we conclude that when choosing a morula for transfer on day 5, there may be a benefit in waiting an extra day for the possibility of blastulation to occur.

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