Early progesterone cessation after in vitro fertilization/intracytoplasmic sperm injection: a randomized, controlled trial  

Oleh:

Kohls, Graciela

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 98 no. 04 (Oct. 2012), page 858-862.
Topik: REPRODUCTION; Luteal phase; progesterone; early withdrawal

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To investigate the effect of stopping progesterone (P) support at week 5 versus week 8 on ongoing pregnancy rate after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Design Prospective, randomized, controlled trial. Setting University-affiliated infertility center. Patient(s) A total of 220 patients with intrauterine pregnancy demonstrated by transvaginal ultrasound after IVF/ICSI. Intervention(s) Luteal phase support with micronized vaginal P was suspended at week 5 or at week 8. Main Outcome Measure(s) Ongoing pregnancy rate, miscarriage rate, and number of bleeding episodes. Result(s) Progesterone levels were similar on the day of the first pregnancy ultrasound exam (149 ± 108 vs. 167 ± 115 ng/mL). Significantly more bleeding episodes were observed in the first trimester in the group with early cessation of P supplementation (18.0 ± 2.6 vs. 7.2 ± 1.3 episodes). Miscarriage rates among singleton pregnancies were similar in the two groups (5/80 vs. 6/79). Conclusion(s) Vaginal P supplementation after IVF/ICSI can be safely withdrawn at 5 weeks' gestation, because cycle outcome was similar to conventional luteal phase support up to 8 weeks of pregnancy.

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