Prediction of the shrinking rate of uterine leiomyoma nodules using needle biopsy specimens  

Oleh:

Kasai, Mari ; Ichimura, Tomoyuki ; Kawamura, Naoki ; Sumikura, Tomoko

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 98 no. 02 (Aug. 2012), page 440-443.
Topik: GYNECOLOGY; Uterine leiomyoma; GnRH-a therapy; menopause; estrogen receptor; vascular endothelial growth factor; menopause

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To determine correlations between shrinkage of uterine leiomyomas after treatment with GnRH agonists (GnRH-a) or menopause and expression levels of estrogen receptors (ER), progesterone receptors (PR), and vascular endothelial growth factor (VEGF). Design Cohort study. Setting University teaching hospital. Patient(s) A total of 26 women with uterine leiomyoma. Intervention(s) Ten women were treated with buserelin acetate injection (1.8 mg), four courses every 4 weeks, and 16 women went into menopause naturally. Main Outcome Measure(s) Tumor shrinkage rates determined from magnetic resonance images taken before and after GnRH-a therapy and before and after natural menopause; immunohistochemical analysis of ER, PR, and VEGF in uterine leiomyoma biopsy specimens taken before intervention or within 6 months before menopause. Result(s) Shrinkage rates of uterine leiomyomas were positively correlated with expression levels of ER in women treated with GnRH-a and in postmenopausal women managed conservatively, and with VEGF expression in women treated with GnRH-a. There were no significant correlations with PR expression levels in either group. Conclusion(s) Estrogen plays the predominant role in myoma shrinkage for women with GnRH-a therapy and naturally menopausal women.

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