Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis  

Oleh:

Prieto, Laura ; Quesada, Juan F. ; Cambero, Olivia ; Pacheco, Alberto

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 98 no. 01 (Jul. 2012), page 126-130.
Topik: ENDOMETRIOSIS; Oxidative stress; endometriosis; infertility

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To study the levels of four markers of oxidative stress in follicular fluid (FF) and plasma of patients with infertility related to endometriosis and controls. Design Experimental study. Setting University-affiliated hospital and infertility center. Patient(s) Ninety-one infertile women were included in the study (23 infertile women with endometriosis and 68 controls including infertile women due to tubal factor, male factor, or healthy egg donors). Intervention(s) Blood was obtained at the time of egg retrieval, and FF from the mature follicles of each ovary was centrifuged and frozen until analysis. Main Outcome Measure(s) Vitamin C and E, malondialdehyde, and superoxide dismutase concentrations in plasma and follicular fluid. Result(s) Women with endometriosis showed a lower vitamin C concentration in FF (12.7 ± 5.9 vs. 9.7 ± 6.9 µg/mL) and lower superoxide dismutase concentration in plasma (0.9 ± 1.4 vs. 0.5 ± 0.7 U/mL) compared with controls. Vitamin E plasma levels were significantly higher in women with endometriosis (8.1 ± 3.8 vs. 5.2 ± 3.2 µg/mL). A nonsignificant trend toward a lower plasma concentration of malondialdehyde was found in women with endometriosis. Conclusion(s) These findings suggest a lower antioxidant capacity in infertile women with endometriosis. Although a certain level of reactive oxygen species is required under physiological conditions, an altered balance between pro-oxidant and antioxidant activities may have an impact on folliculogenesis and adequate embryo development.

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