Role of routine monitoring of liver and renal function during treatment of ectopic pregnancies with single-dose methotrexate protocol  

Oleh:

Clark, Lindsay E. ; Bhagavath, Bala ; Wheeler, Carol A. ; Frishman, Gary N.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 98 no. 01 (Jul. 2012), page 84-88.
Topik: EARLY PREGNANCY; Single-dose methotrexate; ectopic pregnancy; methotrexate side effects

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To assess whether or not baseline serum transaminases and creatinine measurements, before administration of methotrexate, identified significant liver or kidney disease, which have the potential to alter the management plan for the treatment of ectopic pregnancies. Design This is a retrospective study of patients treated for ectopic pregnancy. Setting Women's emergency room and reproductive endocrinology office at a teaching hospital over a 3-year period. Patient(s) Women presenting for treatment of ectopic pregnancy. Intervention(s) None. Main Outcome Measure(s) Assessment of baseline serum transaminases and creatinine measurements before administration of methotrexate to identify significant liver or kidney disease. Result(s) A total of 383 patients were managed for ectopic pregnancy from January 2006 to December 2008. Of these, 320 patients received methotrexate as part of their treatment. No patient was denied treatment with methotrexate secondary to concerns regarding liver or renal function. No complication related to methotrexate administration was documented. A subgroup of 81 patients had pre- and postadministration labs, and no significant difference was noted upon comparing the values. Conclusion(s) Routine measurement of serum aspartate aminotransferase and creatinine levels may not be necessary before instituting a single-dose methotrexate treatment regimen for the management of ectopic pregnancy.

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