Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios  

Oleh:

Gregoriou, Odysseas ; Bakas, Panagiotis ; Grigoriadis, Charalampos ; Creatsa, Maria

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 98 no. 01 (Jul. 2012), page 48-51.
Topik: ANDROLOGY; Aromatase inhibitors; male infertility; oligospermia; letrozole; anastrazole

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To compare the effects of 2.5 mg letrozole with those of 1 mg anastrazole daily on the hormonal and semen profiles of a subset of infertile men with low T/E2 ratios. Design Prospective, nonrandomized study. Setting Reproductive medicine clinic. Patient(s) The study group consisted of 29 infertile men with a low serum T/E2 ratio (<10). Intervention(s) Patients were divided into two groups. Group A included 15 patients treated with 2.5 mg letrozole orally once daily for 6 months, and Group B consisted of 14 patients treated with 1 mg anastrazole orally every day for 6 months. Main Outcome Measure(s) Hormonal evaluation included measurement of serum FSH, LH, PRL, T, and E2. In all sperm analyses pretreatment and posttreatment total motile sperm counts (ejaculate volume × concentration × motile fraction) were evaluated. Result(s) The use of aromatase inhibitors (either letrozole or anastrazole) in cases of infertile men with low T/E2 ratios improved both hormonal and semen parameters. Conclusion(s) This study suggests that some men with severe oligospermia, low T levels, and normal gonadotropin concentration may have a treatable endocrinopathy.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali