Childhood adversity and DNA methylation of genes involved in the hypothalamus–pituitary–adrenal axis and immune system: Whole-genome and candidate-gene associations  

Oleh:

Bick, Johanna ; Naumova, Oksana Yu. ; Hunter, Scott ; Barbot, Baptiste ; Lee, Maria ; Luthar, Suniya S. ; Raefski, Adam ; Grigorenko, Elena L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 24 no. 4 (Nov. 2012), page 1417-1425.
Topik: Childhood Adversity; Immune System; Pituitary; Hypothalamus

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.23 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

In recent years, translational research involving humans and animals has uncovered biological and physiological pathways that explain associations between early adverse circumstances and long-term mental and physical health outcomes. In this article, we summarize the human and animal literature demonstrating that epigenetic alterations in key biological systems, the hypothalamus–pituitary–adrenal axis and immune system, may underlie such disparities. We review evidence suggesting that changes in DNA methylation profiles of the genome may be responsible for the alterations in hypothalamus–pituitary–adrenal axis and immune system trajectories. Using some preliminary data, we demonstrate how explorations of genome-wide and candidate-gene DNA methylation profiles may inform hypotheses and guide future research efforts in these areas. We conclude our article by discussing the many important future directions, merging perspectives from developmental psychology, molecular genetics, neuroendocrinology, and immunology, that are essential for furthering our understanding of how early adverse circumstances may shape developmental trajectories, particularly in the areas of stress reactivity and physical or mental health.

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