Hormonal Contraceptandi onP hysiology: A Research-baseTdhe ory of Discontinuation Due to Side Effects  

Oleh:

Vitzthum, Virginia J. ; Ringheim, Karin

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Studies in Family Planning vol. 36 no. 01 (Mar. 2005), page 13-32.
Topik: Hormonal Contraception; Physiology; The Pharmacology of Hormonal Contraception; Reproductive Hormones
Fulltext: s26 v36 n1 p13 2005 win.pdf (4.32MB)

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Perpustakaan PKPM Nomor Panggil: S26 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Side effects influence the acceptability and continuation of hormonal contraceptives. Counseling the client about the management of side effects is a principal approach advocated for increasing continuation. Evidence of a biological basis for variation in women's tolerance of hormonal contraceptivesa rgues, however,t hatg reatera ttention should be given to altering the productr ather than principally attempting to alter a woman's ability to deal with the product. Discontinuation rates for hormonal contraceptives, largely attributable to side effects and health concerns, are high in nearly all less-developedc ountriesf or which Demographica nd Health Survey data are available. Oral contraceptivesa ppeart o be particularlyp roblematicfo r Latin American women, most notably in Bolivia. Clinical trials suggest substantial variation in the physiological response to exogenous hormones, and new evidence confirms the hypothesis that the normal hormonal profiles of Bolivian women are significantly lower than those of women in the United States. These findings suggest a needf or morep opulation-specificp hysiologicalr esearchl inked to analyses of the possiblea ssociation between endogenous hormone differences and contraceptive continuation. Appropriately adjusting the level of the steroid delivered may benefit women's health and improve the acceptability and continuation of hormonalc ontraceptives.

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