Perbedaan ekspresi TGF-ß1 dan Fibrosis Interstisial pada Kejadian Nefrotoksis Doxorubicin dan Nefroprotektif Pentoxifylin  

Oleh:

Purwanto, Bambang

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Jurnal Kedokteran YARSI vol. 17 no. 02 (May 2009), page 142-149.
Topik: doxorubicin; pentoxyfilline; interstitial fibrosis; albuminuria
Fulltext: J51 v17 n2 2009 p142.pdf (3.36MB)

Ketersediaan

Perpustakaan PKPM Nomor Panggil: J51 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk
Perpustakaan FK Nomor Panggil: J26.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk

Isi artikel

Nephrotoxic effects of Doxorubicin (DXR) is still a problem in clinical practice. On the other hand Pentoxyfilline (PTX) as an electron-donor material can be nephroprotective. Therefor, combination of DXR and PTX would be expected to reduce nephrotoxic effects of DXR. In this study we examined the effects of PTX on TGF-ß1 expression and interstitial fibrosis in an experimental model of DXR nephropathy in mice. Mice were divided into three groups of eight each i.e untreated swiss mice (controls), DXR treatment alone to induce nephropathy, and DXR treatmentfolloed by PTX. Following 4 week treatment, each group was sacrificed. Examination of TGF-ß1 expression was carried out by immunohistochemistryemploying monoclonal antibody. Interstitial fibrosis examination was performed by a histopathologist using Verheoff van Giesen staining and the one way Anova was used for statitical analysis. It was observed that DXR treatment followed by PTX treatment prevented the increase of TGF-ß1 expression and interstitial fibrosis in mice with DXR-nephropathy (p<0.05). These findings suggested the beneficial nephroprotective effect of PTX.

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