Protective effect of Brassica oleracea var. botrytis L. against theophylline-induced hepatocellular abnormalities in rats  

Oleh:

Sunarsih, Endang Sri ; Hakim, Lukman ; Sugiyanto ; Sumantri

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Universa Medicina vol. 31 no. 01 (Jan. 2012), page 12-19.
Topik: Cauliflower extract; theophylline; liver microscopic appearance; Wistar rats
Fulltext: Endang-Sri-Sunarsih.pdf (145.14KB)

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Perpustakaan FK Nomor Panggil: U01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

BACKGROUND Indole and its derivatives, such as indole acetic acid are active constituents ofcauliflower (Brassica oleracea var. botrytis L.) with are known to function asplant growth hormones. Drug metabolism mainly occurs in the liver, so thatthe possibility of damage to this organ is considerable. The purpose of thisstudy was to evaluate the effect of cauliflower extract on alanine transaminase(ALT) levels and on the hepatocyte morphology induced by theophylline inWistar rats. METHODS Twenty Wistar rats were divided randomly into four groups. Group I was givenonly theophylline 20 mg/kg BW. Groups II, III, and IV were given cauliflowerextract 200 g/kg BW, for 5, 10, 15 days, and on the last day were giventheophylline 20 mg/kg BW. On days 5, 10, and 15 the animals were terminated,their livers taken and observed for microscopic appearance, while blood sampleswere taken for measuring ALT levels. RESULTS Cauliflower affected a reduction in ALT levels, mean serum ALT concentrationin rats given cauliflower for 5 days (109.86 ± 2.20 IU/L was significant highercompared to rats given cauliflower for 15 days (71.58 ± 3.17 IU/L) (p=0.000).Mean values of histopathologic liver cells in rats given cauliflower for 15 days(1.17 ± 0.01) significant lower compared to rats given cauliflower for 5 days(1.45 ± 0.06) (p=0.000).CONCLUSIONSCauliflower extract reduced the level of ALT and improved the microscopicappearance of hepatic cells in the rats. Cauliflower extract could lead to thedevelopment of potent anti-tumor agents for hepatic cancer treatment.

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