Isoflavone supplementation reduced serum sex hormonebinding globulin concentration in postmenopausal women  

Oleh:

Parwanto, ML. Edy ; Indrawati, Yanti ; SETIAWAN, HERMAN

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Universa Medicina vol. 31 no. 01 (Jan. 2012), page 52-62.
Topik: Isoflavones; calcium; sex hormone-binding globulin; postmenopausal women
Fulltext: edy-parwanto.pdf (66.24KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: U01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

INTRODUCTION The bone loss that occurs with ageng in postmenopausal women is related to adecrease in serum levels of bioavailable estrogen and testosterone, which aremainly bound to sex hormone-binding globulin (SHBG) and albumin.Phytoestrogens are thought to exert hormonal effects in the body due to theirstructural resemblance to 17â-estradiol. The objective of this study was toevaluate the effect of isoflavone supplementation on levels of SHBG inpostmenopausal women aged 47- 60 years. METHODS A study of pre and post test design with controls was conducted in 70 womenaged 47- 60 years. Subjects were randomly divided into 2 groups, the isoflavonegroup received 100 mg isoflavones/day + calcium 500 mg/day and the controlgroup calcium 500 mg/day for 6 months. Measurement of bone mineral densitywas performed prior to supplementation, and serum SHBG levels before andafter supplementation. RESULTS Supplementation of isoflavones for 6 months reduced the SHBG levels by 31.1%in the isoflavone group (p=0.000), whereas supplementation of calcium for 6months did not affect the levels of SHBG in the control group (p=0.359).Supplementation of isoflavones for 6 months reduced SHBG levels ofpostmenopausal women in the isoflavone group with either osteopenia(p=0.028) or osteoporosis (p=0.008). CONCLUSION Supplementation of isoflavones for 6 months decreased the SHBG levels ofpostmenopausal women in the isoflavone group with osteopenia andosteoporosis. Our findings suggest that phytoestrogens may significantlydecreased SHBG levels in postmenopausal women.

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