Respon Klinis dan Parasitologis Dihidroartemisinin - Piperakuin pada Subyek Malaria Falsiparum dan Malaria Vivaks pada Hari Ke-3 Kunjungan Ulang  

Oleh:

Risniati, Yenni ; Hasugian, Armedy Ronny ; Siswantoro, Hadjar ; Avrina, Rossa ; Tjitra, Emiliana ; Delima

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Media Penelitian dan Pengembangan Kesehatan vol. 21 no. 04 (Dec. 2011), page 157-165.
Topik: Malaria; dihidroartemisinin-piperakuin; respon klinis; respon parasitologis; H3
Fulltext: 79-146-1-SM.pdf (469.89KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: M32.K Non-tandon: 2 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Clinical and parasitological response of malaria treatment on day 3 follow-up (D3) is a crucial condition to predict the successful of treatment. D3 is a period time that Early Treatment Failure may happen which may cause severe or complicated malaria. Moreover, if the asexual parasitemia is still detected more than 10% study subjects, it is assumed parasites resistance against artemisinin. Methods: Analysis used data from Monitoring Drug Resistance In Subject With P.falciparum And P.vivax Malaria In Kalimantan And Sulawesi. Clinical data was gotten from anamnesis to identify clinical symptoms and physical examination including vital and clinical signs that was notified in case report form (CRF). Parasitological data was cross check examination from NIHRD microscopist for parasite density, and PCR examination result for Plasmodium detection and speciation that were recorded in log book and/or CRF. Clinical and parasitological response of DHP was examined with compared the condition of falciparum and vivax malaria on D0 (before treatment) and D3 (after 3 days treatment with completed dose). Result: Total malaria subject that were analyzed 206 subject, that were 119 falciparum malaria and 87 vivax malaria. Proportion subject falciparum and vivax malaria with clinical symptoms deceased significantly on D3 (p<0.05), accepted diarrhea on subject with vivax malaria. Proportion clinical signs also decreased significantly on D3, accepted dyspneu on falciparum malaria subject. From 206 malaria subject, only 1 subject (0,8%) with falciparum malaria that still was found asexual parasite with low density (10/ul). Proportion subject with gametocyte also decreased significantly on falciparum malaria (p=0,000) and vivax malaria (p=0,000). Conclusion: Clinical and parasitological response of DHP in falciparum and vivax subjects was excellent by D3. Only one falciparum malaria subject (0,8%) was still detected asexual parasitemia with the density of 10/ul. DHP has rapid action and no clear signs artemisinin resistance.

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