Hubungan Kepadatan Parasit dengan Manifestasi Klinis pada Malaria Plasmodium Falciparum dan Plasmodium Vivax  

Oleh:

Avrina, Rossa ; Risniati, Yenni ; Siswantoro, Hadjar ; Hasugian, Armedy Ronny ; Tjitra, Emiliana ; Delima

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Media Penelitian dan Pengembangan Kesehatan vol. 21 no. 03 (Sep. 2011), page 119-126.
Topik: malaria; Plamodium falciparum; Plasmodium vivax; clinical manifestation
Fulltext: 93-174-1-SM.pdf (170.65KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: M32.K Non-tandon: 2 (dapat dipinjam: 0) Tandon: tidak ada

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Malaria is still a public health problem in Indonesia. The clinical manifestation of malaria is varied, and many factors may influence its clinical manifestation. Despite the species of malaria, density of parasitemia is known related to the severity or malignancy of malaria. It is worth to analyse the clinical and laboratory data of malaria cases in monitoring dihydroartemisinin-piperaquine (DHP) treatment. The extended analysed was done to assess the relationship between density of parasitemia and clinical manifestations. A subset data of monitoring DHP treatment in subjects with uncomplicated falciparum and vivax malaria in Kalimantan and Sulawesi which were consist of clinical and laboratory day-0 data was used in analysing. Clinical data were recorded through anamnesis and physical examination. Parasite density was counted by health centre microscopist and then cross-checked by certified microscopists of the Natiional Institute of Health Reseach and Development. Haemoglobin level was also measured by health centre analyst using the existing Sahli hemoglobinmeter. For parasite density category, median is used for cut off point. In P.falciparum malaria, the cut off point is 5588/µl and in P.vivax malaria is 3375/µl. The relationship between parasite density and clinical manifestation in falciparum and vivax malaria was determined by bivariate and multivariate analysis with logistic regression using SPSS 17 software. The most of subject with P.falciparum and P.vivax malaria are children (<15 yeras old), male, and non indigenous. From analysis bivariate, variabels that can be analyzed by multivariate in P.falciparum malaria (p<0,25) are children under 15 years old (p=0,0 12) and Sulawesi island where subject live(p=0,163) and In P.vivax malaria is children under 15 years old (p=0,218). Because of other variables are considered biologicaly related to parasite density, therefore all variabel are analyzed with multivariate. From multivariate analysis, there is significant relationship between parasite density and chidren under 15 years old in P.falciparum malaria (OR = 0,4, CI95%= 0,2-1,0). In P.vivax malaria, parasite density is related to children under 15 years old (OR = 0,6, CI 95% =0,2-1,9), haemoglobin level under 11gr/dl (OR= 1,4, CI 95%= 0,5-3,8), non indigenous OR= 0,3, CI 95%= 0,1-1,2) and the sum of clinical symptom <7 (OR=0,7, CI 95%=0,3-1,9). Parasite density is not related with clinical manifestation in P.falciparum malaria.. Parasite density is related to children under 15 years old significantly in P.falciparum malaria. In P.vivax malaria, parasite density are related to children under 15 years old, anemia, non indigenous, and the sum of clinical symptom <7. But the relationship isn’t significant.

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