Genotype distribution of T cell receptor ß gene in Indonesian nasopharyngeal carcinoma patients  

Oleh:

Yurnadi ; Soeharso, Purnomo ; Suryandari, Dwi A. ; Moeloek, Nukman ; Susworo, R.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Medical Journal of Indonesia vol. 20 no. 3 (Aug. 2011), page 171-177.
Topik: EBV; NPC; polymorphism; susceptibility; TCR-ß gene
Fulltext: Volume 20, Issue 3, August 2011 - Genotype distribution of T cell receptor β gene in Indonesian nasopharyngeal carcinoma patients.pdf (469.99KB)

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Perpustakaan FK Nomor Panggil: M35.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Nasopharyngeal carcinoma (NPC) is a multifactorial genetic disease, characteristically endemic and shows considerable differences in its geographical distribution. Besides infection with EBV, genetic factors such as polymorphisms of TCR-ß gene contribute to the incidence of NPC. This study investigates the association of TCR-ß gene polymorphisms with individual susceptibility to develop NPC in Indonesian ethnic groups. Methods: The study was carried out by the PCR-RFLP method using Bgl II restriction enzyme to digest TCR-ß gene. The PCR-RFLP analysis of TCR-ß gene was used to determine allotypes of TCR-ß gene in NPC patients and control among ethnic Chinese and indigenous groups in the population of Indonesia. Results: The results indicate that the distribution of TCR-ß gene allotypes between NPC patients and controls are not signifi cantly different (p > 0.05); however, the frequency of A allele tends to increase in NPC patients. The distribution of TCR-ß gene allotypes between Chinese ethnic group was not signifi cantly different from indigenous groups (p > 0.05). Conclusion: The distribution of TCR-ß gene allele between NPC group and control groups showed no difference. The distribution of TCR-ß gene between ethnic Chinese and indigenous groups showed no difference. Polymorphisms of TCR-ß gene are not associated with NPC and ethnic groups in Indonesian population. (Med J Indones 2011; 20:171-7)

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