Synthesizing Derivatives from Cyclopentanone Analogue Curcumin and Their Toxic, Antioxidant and Anti-Inflammatory Activities  

Oleh:

Eryanti, Yum ; Nurulita, Yuana ; Hendra, Rudi ; Yuharmen ; Syahri, Jufrizal ; Zamri, Adel

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Sains vol. 15 no. 2 (Nov. 2011), page 117-123.
Topik: Antioxidant; Anti-Inflammatory; Curcumin; Toxicity
Fulltext: Yum Eryanti.pdf (230.08KB)

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Perpustakaan Pusat (Semanggi) Nomor Panggil: MM65 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Three types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives under a base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone (a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b), and 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (c) which has a yield of 63-99%. The chemical structure of these compounds were determined using UV, IR and NMR spectroscopy. In order to clarify the role of hydroxyl and amine moieties, toxic, antioxidant and anti-inflammatory activities were carried out. The toxic test indicated that the compounds showed strong toxicity. In addition, the presence of hydroxyl and amine groups on both rings of curcumin increased the antioxidant and anti-inflammatory activities.

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