Detail Seroconversion Rates in Kidney Transplant Recipients Following SARS-CoV-2 Vaccination and its Association with Immunosuppressive Agents: A Systematic Review and Meta-Analysis (Article of Clinical and Experimental Vaccine Research Vol. 12 Iss. 1 Januari 2023 p. 13-24) Bibliografi Author: Iryaningrum, Maria Riastuti ; Cahyadi, Alius ; Damara, Fachreza Aryo ; Bandiara, Ria ; Marbun, Maruhum Bonar Hasiholan Topik: Kidney transplant; SARS-CoV-2; Seroconversion; Transplantation; Vaccine Bahasa: (EN )     Penerbit: Korean Vaccine Society     Tahun Terbit: 2023     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: B4. Publikasi.pdf (936.44KB; 2 download) Abstract This systematic and meta-analysis aims to evaluate humoral and cellular responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine among kidney transplant recipients (KTRs). We conducted a systematic literature search across databases to evaluate seroconversion and cellular response rates in KTRs receiving SARS-CoV-2 vaccines. We extracted studies that assessed seroconversion rates described as the presence of antibody de novo positivity in KTRs following SARS-CoV-2 vaccination published up to January 23rd, 2022. We also performed meta-regression based on immunosuppression therapy used. A total of 44 studies involving 5,892 KTRs were included in this meta analysis. The overall seroconversion rate following complete dose of vaccines was 39.2% (95% confidence interval [CI], 33.3%–45.3%) and cellular response rate was 41.6% (95% CI, 30.0%–53.6%). Meta-regression revealed that low antibody response rate was significantly associated with the high prevalence of mycophenolate mofetil/mycophenolic acid (p=0.04), belatacept (p=0.02), and antiCD25 induction therapy uses (p=0.04). Conversely, tacrolimus use was associated with higher antibody response (p=0.01). This meta-analysis suggests that postvaccination seroconversion and cellular response rates in KTRs are still low. And seroconversion rate was correlated with the type of immunosuppressive agent and induction therapy used. Additional doses of the SARS-CoV-2 vaccine for this population using a different type of vaccine are considered. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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