Detail Peptide extracts from tempeh protect against photoaging via down-regulating matrix metalloproteinase-3 gene expression (article of Jurnal Teknologi Vol. 82 No. 1: January 2020) Bibliografi Author: Hallis, Steffanus Pranoto ; Yanti ; Suhartono, Maggy Thenawidjaja ; Ali, Soegianto Topik: Tempeh; peptide extracts; anti-photoaging activity; UVB-induced mice; MMP-3 Bahasa: (EN )     Penerbit: Penerbit UTM Press, Universiti Teknologi Malaysia     Tempat Terbit: Johor Bahru    Tahun Terbit: 2020     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: Peptide extracts from tempeh protect against photoaging.pdf (766.14KB; 1 download) [Informasi yang berkaitan dengan koleksi ini di internet] Abstract Photoaging damages skin tissue via activation of matrix metalloproteinases (MMPs) and MMP-3 induces activation of MMP-1 and 9. Tempeh is made from fermented soybean in Indonesia and has been known for its high protein content. This study was aimed to investigate the effectiveness of peptide extracts from tempeh against photoaging at gene level in UVB-treated mice. Peptide was extracted from soybean and black soybean tempeh, and identified for its amino acid profiling. Photoaging model was made by gradient UVB exposure to seven groups of mice for 4 weeks. Mice were supplemented with 100 and 300 mg/kg body weight dosages of peptide extracts from soybean and black soybean tempeh. Dorsal skin tissue was collected for histology staining and quantitative polymerase chain reaction (qPCR). This present study found that both tempeh peptide extracts were rich in glutamic acid and branched-chain amino acids. Histology staining showed that tempeh protected mice skin from photoaging. At 100 and 300 mg/kg, both tempeh peptide extracts significantly attenuated MMP-3gene expression that lead to the decrease level of MMP-1 and MMP-9 gene expression. These results suggest that supplementation of both tempeh peptide extracts may possess anti-photoaging effect via altering MMP-3 gene expression in UVB-treated mice. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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