Pharmacology of Commonly Used Analgesics and Sedatives in the ICU: Benzodiazepines, Propofol, and Opioids  

Oleh:

Devlin, John W. ; Roberts, Russel J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Anesthesiology Clinics (keterangan: ada di ClinicalKey) vol. 29 no. 04 (Dec. 2011), page 567-585.
Topik: Sedation; Analgesia; Critical care; Midazolam; Lorazepam; Propofol; Opioids; Fentanyl

Ketersediaan

Perpustakaan FK Nomor Panggil: A34.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Opioids, benzodiazepines, and propofol remain the mainstay by which to optimize patient comfort and facilitate mechanical ventilation in patients who are critically ill. Unfortunately none of these agents share all of the characteristics of the ideal sedative or analgesic agent: rapid onset, rapid recovery, a predictable dose response, a lack of drug accumulation, and no toxicity. To optimize care, critical care clinicians should be familiar with the many pharmacokinetic, pharmacodynamic, and pharmacogenetic variables that can affect the safety and efficacy of these sedatives and analgesics.

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