Inhibin a gene promoter polymorphisms in Korean women with idiopathic premature ovarian failure  

Oleh:

Yoon, Sang Ho ; Choi, Young Min ; Hong, Min A. ; Kim, Jin Ju

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Human Reproduction vol. 27 no. 06 (Jun. 2012), page 1870-1873.
Topik: REPRODUCTIVE GENETICS; inhibin a; single-nucleotide polymorphisms; premature ovarian failure

Ketersediaan

Perpustakaan FK Nomor Panggil: H07.K.2012.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

BACKGROUND It has been suggested that variations in the inhibin a gene (INHA) may affect the ovarian function of women. This study was performed to investigate whether the genetic polymorphisms of the INHA gene are associated with idiopathic premature ovarian failure (POF) in a Korean population. METHODS The subjects consisted of 159 idiopathic POF patients and 233 post-menopausal controls. Genotyping for the –16C>T polymorphism was performed by an minor groove binder (MGB) primer/probe Taqman assay, and the –124A>G polymorphism was identified using PCR restriction fragment length polymorphism analysis. Haplotypes were deduced by using the Haploview version 4.1. RESULTS There were no significant differences in the genotype distributions or allele frequencies of the INHA gene –16C>T and –124A>G polymorphisms between the POF and the control group. Haplotype analysis also showed no significant difference between groups. CONCLUSIONS The distribution of the INHA gene promoter polymorphisms in a Korean POF population was not significantly different from controls, implying that the INHA gene polymorphisms may not be associated with the risk of idiopathic POF.

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