Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3  

Oleh:

Zhao, Hanxin ; Xu, Xinghua ; Xing, Xiuye ; Wang, Jianfeng

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Human Reproduction vol. 27 no. 01 (Jan. 2012), page 294-298.
Topik: REPRODUCTIVE GENETICS; polycystic ovary syndrome; transmission disequilibrium test; single-nucleotide polymorphism; genome wide association study

Ketersediaan

Perpustakaan FK Nomor Panggil: H07.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

BACKGROUND Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder. A previous genome-wide association study (GWAS) identified five single nucleotide polymorphisms (SNPs) which were independently associated with PCOS in Han Chinese. To overcome population strati?cation, a family-based analysis was conducted to validate whether these five SNPs are associated with PCOS. METHODS A total of 276 family trios (828 participants) having a proband with PCOS were included in the family-based study. The transmission disequilibrium test (TDT) was used to analyze the association between PCOS and five SNPs rs13429458, rs12478601, rs13405728, rs10818854 and rs2479106 in three susceptible loci 2p16.3, 2p21 and 9q33.3. RESULTS A positive association was observed for the SNP rs13429458 (P= 3.74 × 10–5). CONCLUSIONS TDT confirms that SNP rs13429458, in the THADA gene, is significantly associated with risk of PCOS. This family-based analysis enhances our previous case–control GWAS and provides further support for the role of susceptibility loci in PCOS.

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