Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis  

Oleh:

Barbosa, Caio P. ; Teles, Juliana S. ; Lerner, Tatiana G. ; Peluso, Carla

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 97 no. 05 (May 2012), page 1124-1128.
Topik: Autoimmunity; endometriosis; infertility; FCRL3 gene; FOXP3 gene; polymorphism

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To consider a possible cumulative effect of two genetic polymorphisms (FOXP3 C-2383T/rs3761549 and FCRL3 C-169T/rs7528684) that were previously shown to be associated with endometriosis. Design Genetic association study. Setting Human reproduction outpatient clinic of Faculdade de Medicina do ABC. Patient(s) One hundred eighty-eight infertile women with endometriosis and 169 controls. Intervention(s) Detection of polymorphisms FOXP3 (C-2383T/rs3761549) and FCRL3 (C-169T/rs7528684) by TaqMan real-time polymerase chain reaction. The results were analyzed statistically. Main Outcome Measure(s) Genotype distribution, allele frequency, and combination analysis of the FOXP3 and FCRL3 polymorphisms. Result(s) Single-marker analysis revealed a significant association of FOXP3 C-2383T and FCRL3 C-169T, independently, with endometriosis-related infertility, regardless of the stage of the disease. Considering the combined genotypes of FCRL3 and FOXP3 polymorphisms, a positive association was found between genotypes FCRL3TT/FOXP3CT, FCRL3CT/FOXP3CT, and FCRL3CC/FOXP3CT and the risk of endometriosis development. Moreover, a progression of the disease risk was observed according to the presence of one or two copies of risk allele FCRL3 C and only one copy of risk allele FOXP3 T (odds ratio [OR] = 2.14, OR = 3.25, and OR = 6.0, respectively, for genotypes FCRL3TT/FOXP3CT, FCRL3CT/FOXP3CT, and FCRL3CC/FOXP3CT). Conclusion(s) Our findings support a possible gene-gene interaction leading to a cumulative effect on endometriosis development.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali