Detail Competing for blood: the ecology of parasite resource competition in human malaria–helminth co-infections (article of Ecology Letters Vol.21, Iss.4 April 2018 P.536-545) Bibliografi Author: Budischak, Sarah A. ; Wiria, Aprilianto E. ; Hamid, Firdaus ; Wammes, Linda J. ; Kaisar, Maria Mardalena Martini ; Lieshout, Lisette van ; Erliyani Sartono ; Supali, Taniawati ; Yazdanbakhsh, Maria ; Graham, Andrea L. Topik: Ascaris lumbricoides; co-infection interactions; Hookworms; Plasmodium falciparum; Plasmodium vivax; resource competition; within-host ecology; JABFUNG-FKIK-MKS-2022-06 Bahasa: (EN )     Penerbit: John Wiley & Sons Ltd     Tempat Terbit: England    Tahun Terbit: 2018     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: B6 Publikasi bu Maria Kaisar.pdf (571.98KB; 1 download) Abstract Ecological theory suggests that co-infecting parasite species can interact within hosts directly, via host immunity and/or via resource competition. In mice, competition for red blood cells (RBCs) between malaria and bloodsucking helminths can regulate malaria population dynamics, but the importance of RBC competition in human hosts was unknown. We analysed infection density (i.e. the concentration of parasites in infected hosts), from a 2-year deworming study of over 4000 human subjects. After accounting for resource-use differences among parasites, we find evidence of resource competition, priority effects and a competitive hierarchy within co-infected individuals. For example reducing competition via deworming increased Plasmodium vivax densities 2.8-fold, and this effect is limited to bloodsucking hookworms. Our ecological, resource-based perspective sheds new light into decades of conflicting outcomes of malaria–helminth co-infection studies with significant health and transmission consequences. Beyond blood, investigating within-human resource competition may bring new insights for improving human health. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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