Diabetes Antibody Standardization Program: First evaluation of assays for autoantibodies to IA-2ß  

Oleh:

Schlosser, Michael ; Mueller, Patricia W. ; Achenbach, Peter ; Lampasona, Vito

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 34 no. 11 (Nov. 2011), page 2410-2412 .
Topik: DIABETES; Autoantibodies to IA-2ß; Diabetes Antibody Standardization Program

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE Autoantibodies to IA-2ß (IA-2ßA) are important risk markers of type 1 diabetes. We report the first Diabetes Antibody Standardization Program (DASP) evaluation of IA-2ßA assays. RESEARCH DESIGN AND METHODS Thirteen laboratories from nine countries received coded sera from 50 patients with newly diagnosed type 1 diabetes and 100 healthy blood donors. IA-2ßA results were analyzed using receiver operating characteristic (ROC) curves. Concordance of antibody levels was compared using counts per minute (cpm), local and standard curve–derived common units. RESULTS Median laboratory-assigned sensitivity was 47% (interquartile range [IQR] 45–51), specificity 98% (IQR 95–99), adjusted sensitivity at 95% specificity 50% (IQR 49–53), and area under the ROC curve 0.70 (IQR 0.69–0.73). Use of common IA-2ßA units improved concordance between assays compared with local units and cpm (P < 0.0001). CONCLUSIONS IA-2ßA assays in multiple laboratories worldwide achieved good concordance and high specificity for type 1 diabetes. IA-2ßA are suitable for inclusion in autoantibody testing for risk assessment in prediabetes.

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