Detail Bixa orellana L. carotenoids: antiproliferative activity on human lung cancer, breast cancer, and cervical cancer cells in vitro (article of Natural Product Research 2022) Bibliografi Author: Kusmita, Lia ; Franyoto, Yuvianti Dwi ; Mutmainah ; Puspitaningrum, Ika ; Nurcahyanti, Agustina Dwi Retno Topik: Bixa orellana L.; Bixaceae; bixin; annatto pigment; pro-oxidant; anti-proliferative; lung cancer; cervical cancer; JABFUNG-FKIK-ADRN-2022-15 Bahasa: (EN )     Penerbit: Taylor & Francis     Tempat Terbit: London    Tahun Terbit: 2022     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: B15 Publikasi Tambahan Bu Agustin-compressed.pdf (284.68KB; 7 download) Abstract Emerging evidence on the potential pro-oxidant effect of carotenoids provokes apoptosis of cancer cells. Bixa orellana L. is native to Central and South America, interestingly, is also cultivated worldwide. Apo-carotenoids present in B. orellana L. are mainly dominated by bixin and norbixin and demonstrate fundamental antioxidant activity. Anti-proliferative activity on human cancer cells is rarely investigated. We isolated bixin from B. orellana L. found in the island of Java using Ultra-Fast Liquid Chromatography and confirmed the isolated compound using Liquid Chromatography-MS/MS. Bixin and crude extract were examined on human lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7). Anti-proliferative activity revealed to be promising on both, the isolated pigment and crude extract. Further investigation on the mechanism of action and effect on other cell lines, both in vitro and in vivo, are required before clinical translation. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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