Detail Bixin and fucoxanthin sensitize human lung cancer and cervical cancer cell to cisplatin in vitro (article of BMC Research Notes Vol.14, 454, 2021) Bibliografi Author: Nurcahyanti, Agustina Dwi Retno ; Kusmita, Lia ; Wink, Michael Topik: Cisplatin; Bixin; Fucoxanthin; Lung cancer; Drug combination; ABC transporter; Pro-oxidant; JABFUNG-FKIK-ADRN-2022-12 Bahasa: (ID )     Penerbit: BioMed Central     Tempat Terbit: London    Tahun Terbit: 2021     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: B12 Publikasi Tambahan Bu Agustin.pdf (1.02MB; 1 download) [Informasi yang berkaitan dengan koleksi ini di internet] Abstract Objective Cisplatin is a conventional anticancer drug that generates reactive oxygen species and causes apoptosis. However, many cancer cells develop alterations in the ATP binding cassette transporter responsible for the uptake and efflux process, which leads to resistance. Many natural products have shown potential to compete with ATP binding cassette transporter and may sensitize resistant cells to cisplatin. Studies have shown pro-oxidant effect of carotenoids that promote apoptosis of cancer cells. Bixin and fucoxanthin are well-known carotenoids with known antioxidant properties, however their bioactivity in lung cancer cells, clinically known to develop resistance due to ATP binding cassette transporter, has been minimally studied. This study is the first to investigate the potential of bixin and fucoxanthin to sensitize human lung cancer cell line, A549 and cervical cancer cell line, HeLa, to cisplatin. Drug combination method developed by Chou and Talalay theorem was employed. Result Employing the best combination ratio, this study shows selective sensitization of cancer cells to cisplatin after bixin and fucoxanthin treatment. Further study on the mechanism of action in specific types of cancer cells is warranted. It may improve cisplatin sensitivity in tumors and rational use of cancer drugs. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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