Stem cell therapy in diabetic foot patients: where are we now?  

Oleh:

Kirana, Stanley ; Stratmann, Bernd

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Medical Journal of Indonesia vol. 20 no. 02 (May 2011), page 154-160.
Topik: Diabetes Mellitus; Endothelial Progenitor Cells; Peripheral Arterial Disease; Stem Cells; Therapeutic Angiogenesis
Fulltext: Volume 20, Issue 2, May 2011 - Stem cell therapy in diabetic foot patients_ where are we now_.pdf (206.67KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: M35.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Diabetic foot (DF) occurs as a concomitant illness of diabetes mellitus (DM). DM is one of the main causes of nontraumatic amputation in Germany with severe peripheral arterial disease (PAD) with critical limb ischemia (CLI) being of major concern. Although modern techniques are available surgical vascularisation and percutaneous intervention are limited. This problem leads increasing numbers of limb amputations in patients with diabetes mellitus. Thephysiological process of angiogenesis, vasculogenes is and arteriogenesis contribute to the growth of collateral vessels in response to obstructive arterial disease causing limb ischemi. In clinical practice the endogenous angiogenic response is often impaired. Therapeutic angiogenesis is an application of biotechnology to stimulate new vessel formation via local administration of pro-angiogenic growth factors in the form of recombinant protein, or gene therapy,or by implantation of progenitor cells or stem cells that will synthe size multiple angiogenic cytokines. This review summarises the endothelial function and dysfunctionin DM, the mechanism of homing, the transplantation method and the status of clinical trials in stem cell fi eld to treat limb ischemia.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali