11-deoxy prostaglandin F2a, a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3(-/-) females  

Oleh:

Ye, Xiaoqin ; Diao, Honglu ; Chun, Jerold

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 97 no. 03 (Mar. 2012), page 757-763.
Topik: Lysophosphatidic acid (LPA) receptor 3; COX-derived prostanoids; prostanoid receptors; prostanoid receptor agonists; 11-deoxy PGF2a; embryo implantation; embryo spacing

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To determine cyclooxygenase-derived prostanoid signaling in alleviating embryo crowding in the Lpar3(-/-) females. Design Experimental mouse model. Setting Research laboratories. Animal(s) Wild-type, Lpar3(+/-), and Lpar3(-/-) mice. Intervention(s) Intraperitoneal (IP) administration of prostaglandin E2 (PGE2), cPGI (a stable analogue of PGI2), and 11-deoxy prostaglandin F2a (11-deoxy PGF2a, a thromboxane A2 receptor agonist) to preimplantation gestation day 3.5 Lpar3(-/-) females. Main Outcome Measure(s) Implantation sites were detected by blue dye reaction and embryo spacing was determined by the distribution of the implantation sites along the uterine horns on gestation day 4.5; pregnancy outcome was measured by litter size at birth. Result(s) Administration of PGE2 + cPGI on gestation day 3.5 Lpar3(-/-) females restored on-time implantation but did not affect embryo spacing or the number of implantation sites detected on gestation day 4.5; PGE2 + cPGI treatment increased litter size at birth. Administration of PGE2 + cPGI + 11-deoxy PGF2a on gestation day 3.5 Lpar3(-/-) females rescued on-time implantation, partially dispersed the clustered implantation sites normally observed in the Lpar3(-/-) females, increased the number of implantation sites detected on gestation day 4.5, and increased litter size at birth. Conclusion(s) The thromboxane A2 receptor agonist 11-deoxy PGF2a can partially alleviate embryo crowding in the Lpar3(-/-) females and embryo crowding likely contributes to reduced litter size in the Lpar3(-/-) females.

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