Expression pattern of osteopontin and avß3 integrin during the implantation window in infertile patients with early stages of endometriosis  

Oleh:

Casals, Gemma ; Ordi, Jaume ; Creus, Montserrat ; Fabregues, Francisco

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Human Reproduction vol. 27 no. 03 (Mar. 2012), page 805-813.
Topik: REPRODUCTIVE BIOLOGY; Endometrium; Endometriosis; Implantation; Integrins; Osteopontin

Ketersediaan

Perpustakaan FK Nomor Panggil: H07.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

BACKGROUND To study endometrial receptivity in terms of osteopontin (OPN) and avß3 integrin expression and co-expression in infertile women with early stages of endometriosis. METHODS We investigated the immunohistochemical expression and co-expression of OPN and avß3 integrin in the endometrium of 20 infertile patients with Stage I or II endometriosis as the only detectable cause of infertility, 20 infertile patients with unexplained infertility and 20 fertile women undergoing tubal sterilization. Two endometrial biopsies were performed during a single menstrual cycle (postovulatory Day +7 to +8 and 4 days later) in each subject. RESULTS No statistically significant differences regarding OPN and avß3 integrin expression were found between infertile patients with endometriosis and the two control groups. There was no significant correlation between OPN and avß3 integrin staining intensity in the mid-luteal phase biopsies in any of the groups studied. CONCLUSIONS Endometrial OPN and avß3 integrin expression or co-expression is not impaired during the window of implantation in patients with Stage I–II endometriosis. Further studies are needed to determine whether these results imply normal endometrial receptivity in such patients or add to the increasing uncertainty about the clinical value of assessing the endometrium with these markers of implantation.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali