N-Acetylcysteine Ameliorates ?-Radiation-induced Deterioration of Bone Quality in the Rat Femur  

Oleh:

Demirel, C. ; Kilciksiz, S. ; Gurgul, S. ; Erdal, N. ; Yildiz, A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 39 no. 06 (Nov. 2011), page 2393-2401.
Topik: Bone Biomechanics; Bone Quality; G-Irradiation; N-Acetylcysteine; Amifostine; Wr-2721

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

This animal study evaluated the radioprotective effects of N-acetylcysteine (NAC) and amifostine on the biomechanical properties of bone in Wistar albino rats of both genders. The rats were randomly divided into four groups of eight: a control group (C); a group given a single dose of 40 Gy of ?-irradiation (R); a group given ?-irradiation plus 200 mg/kg amifostine (R + amifostine); and a group given ?-irradiation plus 1000 mg/kg NAC (R + NAC). Extrinsic and intrinsic properties of bone, bone mineral density (BMD) and the cross-sectional area of the femoral shaft were determined. The cross-sectional area was significantly higher in the R + NAC and R + amifostine groups compared with the R and C groups. The BMD, maximum load and stiffness were also significantly higher in the R + NAC and R + amifostine groups than in the R group, and energy absorption capacity was higher in the R + NAC group than in the R group. These findings indicate that NAC and amifostine preserve bone quality in rats exposed to ?-irradiation.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali