Long-term, High Intake of Vitamin C Decreases Size and Increases Quantity of Liver Mitochondria in Guinea-pig  

Oleh:

Feuring, M. ; Schultz, A. ; Hersemeyer, K.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 39 no. 06 (Nov. 2011), page 2330-2334.
Topik: Vitamin C; Thyroid Hormones; Mitochondria; Liver; Guinea-Pigs

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Microsomal cytochrome P450 is an important enzyme involved in drug metabolism and bioactivation in the liver. In guinea-pigs, the specific amount of cytochrome P450 depends on dietary vitamin C intake. Short-term vitamin C treatment can induce non-genomic effects on hepatocytes, such as activating mitochondrial respiration without changing cytochrome concentration. The aim of this investigation was to elucidate the long-term effects of a low or high vitamin C diet on the quantity and size of mitochondria in the hepatocytes of guinea-pigs. After 6 - 8 weeks of vitamin C feeding, the group receiving a low vitamin C content in their food (10 mg/100 g food) had significantly less mitochondria, but of a larger size, than the group receiving a high vitamin C content (680 mg/100 g food). This animal model investigation demonstrated that treatment with long-term vitamin C can induce morphological changes in the mitochondria of hepatocytes.

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