Let-7c MicroRNA Expression and Clinical Significance in Hepatocellular Carcinoma  

Oleh:

Zhu, X-M ; Wu, L-J ; Xu, J. ; Yang, R. ; Wu, F-S

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 39 no. 06 (Nov. 2011), page 2323-2329.
Topik: Micrornas; Mirnas; Let-7c; Hepatocellular Carcinoma; Differentiation

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

MicroRNAs (miRNAs) are small non-coding regulatory RNAs that are often dysregulated during carcinogenesis. Downregulation of let-7 miRNA in many human cancers indicates its role in tumourigenesis. This study evaluated the levels of let-7c miRNA, using real-time reverse transcription-polymerase chain reaction, between 32 hepatocellular carcinoma (HCC) tissues and matched normal adjacent tumour tissues within the context of the patient's clinical pathology. Levels of let-7c miRNA were significantly lower in HCC tissues than in corresponding normal adjacent tumour tissues and there was a correlation between the downregulation of let-7c and poor tissue differentiation in HCC. There was no correlation between let-7c miRNA levels and other clinicopathological factors, such as patient age, sex, hepatitis B virus status, a-fetoprotein levels, tumour size, tumour number, the presence of cirrhosis, liver envelope invasion or portal vein thrombosis. These data suggested that let-7c microRNA may play a role in regulating HCC cell differentiation.

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