Observation of Curative Efficacy and Prognosis Following Combination Chemotherapy with Celecoxib in the Treatment of Advanced Colorectal Cancer  

Oleh:

Jin, C-H ; Wang, A-H ; Chen, J-M ; Li, R-X

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 39 no. 06 (Nov. 2011), page 2129-2140.
Topik: Celecoxib; Cyclooxygenase -2 Inhibitors; Folfox4; Colorectal Cancer; Cyclooxygenase -2; COX-2; Efficacy; Prognosis

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

This study investigated the antitumour and chemosensitizing effects of celecoxib in the treatment of advanced colorectal cancer. A total of 90 patients were randomly divided into two groups: group CF was treated with a combination of celecoxib and the folinic acid-fluorouracil-oxaliplatin (FOLFOX4) regimen; and group F was treated with the FOLFOX4 regimen alone. Immunohisto chemical analysis of tumour tissues for cyclooxygenase-2 (COX-2) protein was performed. With regard to short-term efficacy, the response and disease control rates were significantly greater in group CF than group F. A log-rank test showed that the 3-year survival rate was significantly greater in group CF than group F. It was concluded that the addition of celecoxib to the FOLFOX4 regimen increased the short-term efficacy and the 3-year survival rate, and improved the quality of life of patients with advanced colorectal cancer. The antitumour and chemo sensitizing effects of celecoxib appeared to be independent of COX-2.

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