Corticotropin-releasing Hormone Enhances the Invasiveness and Migration of Ishikawa Cells, Possibly by Increasing Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9  

Oleh:

Jo, YH ; Choi, Y.J. ; Kim, H.O. ; Yoon, K.S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 39 no. 06 (Nov. 2011), page 2067-2075.
Topik: Corticotropin-Releasing Hormone; CRH; Endometrial Cancer; Proliferation; Invasion; Migration; Matrix Metalloproteinase

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Corticotropin-releasing hormone (CRH), synthesized in the hypothalamus, is also produced at several extrahypothalamic sites and in normal endometrial cells. CRH exerts antiproliferative activity on oestrogen-dependent tumour cell lines (Ishikawa cells and breast cancer cells) via the CRH receptor-1. This study investigated the potential role of CRH as a factor affecting endometrial migration and invasion in Ishikawa cells, and the possible mechanisms involved in this process. Increasing concentrations of CRH (1, 10 and 100 nM) significantly reduced the proliferation of Ishikawa cells but increased the invasiveness these cells compared with the control group. All three concentrations of CRH significantly increased matrix metalloproteinase (MMP)-2 and MMP-9 levels in Ishikawa cells. In conclusion, CRH inhibited the growth of Ishikawa cells but enhanced their invasiveness, possibly by increasing MMP-2 and MMP-9 levels. These findings suggest that CRH might induce invasion and migration by upregulating MMP-2 and MMP-9 in endometrial cancer.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali