Association of sex hormone receptor gene polymorphisms with recurrent pregnancy loss: a systematic review and meta-analysis  

Oleh:

Mei-Tsz, Su ; Lin, Sheng-Hsiang ; Chen, Yi-Chi

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 96 no. 06 (Dec. 2011), page 1435-1444.
Topik: Meta-analysis; recurrent pregnancy loss; progesterone receptor; estrogen receptor; X chromosome inactivation

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2011.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate the genetic association between estrogen and progesterone receptor polymorphisms (ER, PR) and skewed X chromosome inactivation (XCI) and idiopathic recurrent pregnancy loss (RPL). Design A systematic review and meta-analysis using electronic database (MEDLINE and EMBASE) up to April 2011. Setting 24 eligible studies from 14 countries. Patient(s) 2,750 RPL patients and 3,123 controls were included. Intervention(s) Meta-analyses by means of random-effects models. Main Outcome Measurement(s) Common polymorphisms of ER and PR and skewed XCI. Result(s) Of 221 potentially relevant studies, 24 case-control studies were included: 6 reports of PR polymorphisms (PROGINS), 6 reports of ER-a (3 each of rs2234693 [PvuII], rs9340799 [XbaI], and B domain) and 12 reports of skewed XCI. The integrated result showed that women with skewed XCI (>90%) had a higher risk for RPL (the summary OR [95% CI]: 2.43 [1.34–4.43]), and the subgroup analysis of those studies that included more than three consecutive miscarriages (5 studies), also showed a significant association with RPL (2.52 [1.16–5.44]). Among studies of PR (PROGINS) and ER (PuvII, XbaI, B domain) polymorphisms in RPL, the summary ORs were 1.46 (0.56–3.79), 0.90 (0.47–1.75), 0.83 (0.53–1.29), and 1.07 (0.43–2.63), respectively. Conclusion(s) Meta-analyses of the available data showed a significant association between skewed XCI and idiopathic RPL. More data on the associations between ER and PR polymorphisms and RPL would be helpful to elucidate their roles in RPL.

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