Relationship between reproductive history, anthropometrics, lifestyle factors, and the likelihood of persistent chemotherapy-related amenorrhea in women with premenopausal breast cancer  

Oleh:

Abusief, Mary E. ; Missmer, Stacey A. ; Ginsburg, Elizabeth S. ; Weeks, Jane C.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 97 no. 01 (Jan. 2012), page 154-159.
Topik: CHEMOTHERAPY; Amenorrhea; breast cancer; gravidity; parity; lifestyle factors; premature menopause

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2012.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Design Retrospective cohort study. Setting Dana Farber Cancer Institute and Brigham and Women’s Hospital. Patient(s) Premenopausal women with breast cancer. Intervention(s) We identified all premenopausal women who received standard adjuvant chemotherapy during 1997–2005 for whom menstrual data were available. Multivariable logistic regression models evaluating persistent amenorrhea at =6 month after completion of chemotherapy were conducted. Main Outcome Measure(s) Persistent chemotherapy-related amenorrhea (CRA) at =6 months from completion of chemotherapy. Result(s) A total of 431 women met eligibility criteria and had =6-months’ follow-up. Women with older (>13 years) vs. younger (12–13 years) age at menarche were more than twice as likely to remain amenorrheic. Current smokers had 2.4 greater odds of CRA vs. never smokers, although this association was not statistically significant (95% confidence interval, 0.86–6.75). Conclusion(s) Few identifiable factors contribute to the variability in CRA among premenopausal women after adjuvant chemotherapy for breast cancer. Further research to improve the prediction of CRA, premature menopause, and infertility in young breast cancer survivors is warranted.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali