Mendelian Disorders of Membrane Trafficking  

Oleh:

De Matteis, Maria Antonietta ; Luini, Alberto

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 365 no. 10 (Sep. 2011), page 927-938.
Topik: Membrane Transport; Mammalian Cells

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Nearly all the molecules that are expressed in mammalian cells reach their correct intracellular locations by virtue of sophisticated transport-and-delivery systems. Central among these is the intracellular membrane-transport apparatus, which is designed to ferry most of the transmembrane proteins and nearly all the secreted proteins — about a third of the human proteome — from their site of synthesis, the endoplasmic reticulum, to their final destinations. Membrane transport is responsible for controlling the size, shape, and molecular composition of most cellular organelles, including the plasma membrane, and for mediating the secretion of thousands of cargo species, including hormones, growth factors, . . .

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