Fixed Drug Eruption  

Oleh:

de SousaIsabel, Cristina Valente Duarte

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 365 no. 06 (Aug. 2011), page 365:e12.
Topik: Anterior Chest
Fulltext: Drug Eruption.pdf (90.35KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

A 35-year-old man presented with a 10-day history of a cutaneous lesion on the left anterior chest. Examination revealed an annular, scaly, blistering, violaceous plaque, 5 cm in diameter, with an erythematous periphery. The lesion had appeared 24 hours after the patient began a self-prescribed course of oral trimethoprim–sulfamethoxazole for a respiratory tract infection. Six months earlier, an identical lesion had appeared in the same location after the patient had taken the same drug for 3 days. This first lesion healed after 3 weeks, but residual hyperpigmentation remained. On the basis of this characteristic presentation, a diagnosis of fixed drug eruption was made. Fixed drug eruptions are common, immune-mediated, cutaneous lesions that are typically of acute onset and appear as annular, edematous, sometimes blistering, reddish-brown to violaceous macules or plaques. Their diagnostic hallmarks include residual hyperpigmentation after healing and recurrence at previously affected sites, with subsequent antigenic challenges. This patient received a prescription for a 3-week course of topical glucocorticoids and was advised to avoid sulfonamides in the future.

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