Sjogren's Syndrome and MALT Lymphoma  

Oleh:

Ornetti, Paul ; Vinit, Julien

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 364 no. 19 (May 2011), page 364:e41.
Topik: Symptomatic Xerostomia; Xerophthalmia
Fulltext: MALT Lymphoma.pdf (49.07KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2011.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

A 73-year-old woman with a history of symptomatic xerostomia and xerophthalmia was hospitalized for evaluation of a neck mass and progressive symptoms of obstructive sleep apnea that had developed during the previous 12 months. The physical examination revealed a nontender enlargement of the lacrimal glands and submandibular salivary glands (Panel A, arrows). The results of Schirmer's test for tear production were abnormal, and serologic analysis showed positive results for anti-SSA autoantibodies, which supported a diagnosis of primary Sjögren's syndrome. Computed tomographic imaging revealed nodular masses in both submandibular glands (Panel B, arrows, axial view) and a 4-cm polypoid mass extending from the root of the tongue to the right epiglottic vallecula (Panel C, arrows, sagittal view). A biopsy sample obtained from the tongue lesion revealed an extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type. Patients with primary Sjögren's syndrome have an increased risk of non-Hodgkin's lymphoma. For this patient, combination chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) resulted in the disappearance of the masses in the tongue and submandibular glands. During the subsequent 24 months, there was complete resolution of the obstructive sleep apnea, xerostomia, and xerophthalmia.

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